Review Article
Open Access
Integrated Phytochemical, Biochemical, and Process Engineering Approaches For The Development Of Bioactive Plant-Based Therapeutics
Winny Verpoorte*, Henry Daniell
Research Institute of pharmacognosy and metabolomics at Leiden University
Winny Verpoorte, et al /Int.J. TechnoChem Res. 2023,9(1),pp 14-21.
Abstract
The increasing demand for safe, effective, and sustainable therapeutics has intensified interest in
plant-derived bioactive compounds. Phytochemicals exhibit diverse pharmacological properties, including
antioxidant, antimicrobial, anti-inflammatory, and anticancer activities, making them valuable candidates for
modern drug development. However, challenges related to extraction efficiency, process scalability, quality
assurance, and reproducibility limit their industrial translation. This study presents an integrated approach
combining phytochemistry, medicinal chemistry, applied biotechnology, microbiology, and chemical process
engineering to develop standardized plant-based therapeutics. Advanced extraction techniques, biochemical
characterization, microbial screening, and process optimization strategies were employed to enhance yield,
bioactivity, and quality consistency. The results demonstrate that techno-chemical integration significantly
improves process efficiency, biological efficacy, and regulatory compliance. This research establishes a
comprehensive framework for translating traditional phytochemicals into scientifically validated and industrially
viable therapeutic products.
Keywords
Phytochemistry; Medicinal chemistry; Chemical process technology; Bioactive compounds; Quality assurance;
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