Review Article
Open Access
Synthesis of Newer Substituted Azetidinone and Thiazolidinone derivatives as potent Anticonvulsant Agents
Archana
Medicinal Chemistry Lab ,Department of Chemistry , Meerut College Meerut – 250001 (UP)
India
Archana/Int.J. TechnoChem Res. 2016,2(2),pp 121-126.
Abstract
Various 2-N-(2-Phenyl -1H-indol-3yl)-imino benzene/thiophenol ( 3a – 3e) , 3-Chloro-1
(benzyl/thiophenyl)-4-(2-1H-indol-3yl) azetidin-2-ones (4a-4e) and 3-Substituted benzyl/thiophenyl -4
(2-phenyl 1H-indol-3-yl) thiazolidin-4-ones (5a-5e) have been synthesised . The structures of these
compounds have been established by elemental (C,H,N) and spectral (IR, H-NMR, and Mass) analysis.
The synthesised compounds were screened in vivo ,for their acute toxicity and anticonvulsant activity in
MES and PTZ models. Almost all compounds have shown promising anticonvulsant activity. Compound
5d was the most potent compound of this series.
Keywords
Substituted Indolyl azetidinones, Substituted Indolyl thiazolidinones, anticonvulsant activity, acute toxicity.
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